Washington University is known worldwide for its extensive experience in treating patients with Multiple Endocrine Neoplasia (MEN) syndromes. These rare, inherited syndromes may produce tumors in the thyroid, parathyroid, adrenal and pituitary glands, and pancreas. (Syndromes are medical conditions that occur in groups of three.)
Researchers at Washington University are credited with identifying the MEN-2 gene and have developed the latest surgical treatments for these syndromes.
MEN-2A (Sipple syndrome) consists of bilateral medullary carcinoma or C cell hyperplasia, pheochromocytoma and hyperparathyroidism. This syndrome is caused by a defective gene, which regulates growth of endocrine tissues.
Patients with MEN-2B have medullary carcinoma and pheochromocytoma but only rarely have hyperparathyroidism. Instead, these patients are more likely to have an unusual appearance characterized by mucosal ganglioneuromas (tumors in the mouth) and marfanoid habitus.
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